| 名稱 | NOTA-PSMA |
| 純度 | 98% |
| 序列（單字母縮寫） | |
| 序列（三字母縮寫） | |
| 基本描述 | |
| 分子量 | 941.05 |
| 化學式 | C45H64N8O14 |
| 存儲條件 | Store at -20°C. Keep tightly closed. Store in a cool dry place. |
| 編碼 | 04010027777 |
| CAS | |
| REFERENCES | |
| 分子圖 |
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| 名稱 | PSMA |
| 純度 | 98% |
| 序列（單字母縮寫） | E-urea-K |
| 序列（三字母縮寫） | Glu-rea-Lys |
| 基本描述 | |
| 分子量 | 319.31 |
| 化學式 | C12H21N3O7 |
| 存儲條件 | Store at -20°C. Keep tightly closed. Store in a cool dry place. |
| 編碼 | 04010059069 |
| CAS | 1025796-69-3 |
| REFERENCES | |
| 分子圖 |
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| 名稱 | PSMA-617 Linker |
| 純度 | 95% |
| 序列（單字母縮寫） | |
| 序列（三字母縮寫） | |
| 基本描述 | Vipivotide tetraxetan Linker (PSMA-617 Linker) 是一種有效的不可降解的肽類 Linker，可用于合成 Vipivotide tetraxetan (PSMA-617)。Vipivotide tetraxetan (PSMA-617) 是用于合成?177Lu-PSMA-617 的配體，177Lu-PSMA-617 是用于研究前列腺癌的一種放射性分子。 |
| 分子量 | 655.74 |
| 化學式 | C33H45N5O9 |
| 存儲條件 | Store at -20°C. Keep tightly closed. Store in a cool dry place. |
| 編碼 | |
| CAS | 1703768-74-4 |
| REFERENCES | Bene?ová M, et al. Albumin-Binding PSMA Ligands: Optimization of the Tissue Distribution Profile. Mol Pharm. 2018 Mar 5;15(3):934-946. |
| 分子圖 |
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| 名稱 | PSMA-617 |
| 純度 | 98% |
| 序列（單字母縮寫） | |
| 序列（三字母縮寫） | |
| 基本描述 | PSMA-617 is a high potent prostate-specific membrane antigen (PSMA) inhibitor, with a Ki of 0.37 nM. |
| 分子量 | 1042.14 |
| 化學式 | C49H71N9O16 |
| 存儲條件 | Store at -20°C. Keep tightly closed. Store in a cool dry place. |
| 編碼 | 04010047319 |
| CAS | 1702967-37-0 |
| IN VITRO | PSMA-617 demonstrates high radiolytic stability for at least 72 h. A high inhibition potency (equilibrium dissociation constant Ki=2.34±2.94 nM on LNCaP; Ki=0.37±0.21 nM enzymatically determined) and highly efficient internalization into LNCaP cells are demonstrated[1]. |
| IN VIVO | Organ distribution with 68Ga-labeled PSMA-617 after 1 h (n=3) reveals a high specific uptake in LNCaP tumors and in the kidneys. The high uptake in the kidneys is nearly completely blocked by coinjection of 2 mg o with the exception of the spleen. Tumor-to-background ratios are 7.8 (tumor to blood) and 17.1 (tumor to muscle) at 1 h after injection. As compared with the 68Ga-labeled version, the organ istribution with 177Lu-labeled PSMA-617 (n=3) show a similar uptake in the LNCaP tumors and in the kidneys. The liver uptake is found to be statistically different. Tumor-to-background ratios determined 1 h after injection show slightly higher values (tumor to blood, 22.1;tumor to muscle, 25.6) than previous organ distribution with 68Ga-labeled PSMA-617[1]. |
| REFERENCES | 1702967-37-0 |
| 分子圖 |
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