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    2. 重組蛋白產品

      名稱 Mouse gp130 / IL6ST / CD130 Protein/重組小鼠 gp130
      規格 20ug
      編號 CZDB-001
      價格 詢價
      中文名 重組小鼠 gp130 / IL6ST / CD130 蛋白
      分子別稱 Ac1055, Gp130, Il-6rb
      分子種屬 Mouse
      表達標簽 His,S
      表達宿主 E. coli
      濃度 > 95 % as determined by SDS-PAGE
      緩沖液 Lyophilized from sterile PBS, pH 7.4
      存儲條件 -70°C,應避免反復凍融。
      基本描述 Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.

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